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EAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKB6BAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABKpHAAAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAAAQqAAAACFQAAAAEKgAAAAhUAAAABCoAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoHoEAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAAAhUAAAAEKgAAAAIVAAAABCoAAAACFQAAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAABCoAAAAIFABAAAQqAAAACBQAQAAEKgAAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAIFABAABAoAIAACBQAQAAQKACAAAgUAEAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAQKACAACAQAUAAECgAgAAgEAFAABAoAIAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAgEAFAAAAgQoAAIBABQAAAIEKAACAQAUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAACBCgAAAAIVAAAAgQoAAAACFQAAAIEKAAAAAhUAAA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)
REVISTA INVESTIGACIÓN Y DESARROLLO I+D • VOLUMEN 13 • ENERO - JUNIO 2021 • P. 103 - 106 • UNIVERSIDAD TÉCNICA DE AMBATO - DIDE • AMBATO - ECUADOR 105
ARTÍCULO RECIBIDO: 04/11/2020
ARTÍCULO ACEPTADO: 08/12/2020
ARTÍCULO PUBLICADO: 31/05/2021
Debido a esta situación, este tipo de ensayos resultan útiles para el rastreo de contactos, la vigilancia serológica, identificación
de pacientes que sufrieron la enfermedad y que pueden ser inmunes y para la detección de pacientes con RT-PCR negativa en
fase de convalecencia. La aplicación simultánea de PCR y la detección de niveles de anticuerpos puede mejorar la sensibilidad
diagnóstica de COVID-19, lo cual contribuiría a identificar personas infectadas con cuadros atípicos o con infecciones subclínicas
(Zhao et al., 2020; Long et al., 2020; Xiaoqin et al., 2020). Cuando se realizan estudios retrospectivos sobre la presencia de
anticuerpos contra SARS-CoV-2, la mayoría de los pacientes que resultan positivo desconocían que estaban infectadas
previamente, y la probable fecha de contagio. Por lo tanto, el período de incubación del virus es imposible de determinar con
precisión, así como el rango de días después de la infección en que la IgM y la IgG comienzan a desarrollarse. Esto hace que
sea imposible construir un modelo preciso de anticuerpos basado en los datos actualmente disponibles, a pesar de los numerosos
y hermosos gráficos que muestran este modelo en forma idealizada. Existe evidencia científica para pensar que un alto
porcentaje de los pacientes con COVID-19 desarrollan anticuerpos protectores (Long et al., 2020; Gao et al., 2020).
En conclusión, las pruebas rápidas en la práctica clínica pueden servir de apoyo al diagnóstico de los pacientes con más de
una semana de inicio de los síntomas. Sin embargo, su resultado tanto positivo como negativo, no debería ser lo único que
prevalezca a la hora de hacer el diagnóstico. En un paciente infectado con el SARS-CoV-2 el diagnóstico no debe depender
de una sola prueba, debe ser el resultado final de la evaluación crítica por parte del médico tratante y otros profesionales de
la salud, de los resultados que incluyen imágenes (tomografías, radiografías, ecosonografía), biomarcadores hematológicos,
bioquímicos e inflamatorios de laboratorio clínico y pruebas microbiológicas específicas para la detección directa o indirecta
de la infección (Aguilar et al., 2020).
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