ORIGIN AND PREVALENCE OF COLONIZATION BY BACTERIA CARRYING EXTENDED-SPECTRUM Β-LACTAMASES AND KLEBSIELLA PNEUMONIAE CARBAPENEMASES IN HOSPITALIZED PATIENTS
DOI:
https://doi.org/10.31243/ei.uta.v10i3.2933.2025Keywords:
colonización, resistencia a antibióticos, resistencia betalactamicas, enterobacteriaceae productoras de carbapenemasaAbstract
Introduction: Intestinal colonization is a significant factor in disseminating multidrug-resistant bacteria and can also be the endogenous origin of bacteria that cause infections. Objective: To determine the prevalence of human carriers of extended-spectrum β-lactamase (BLEE) and Klebsiella pneumoniae carbapenemase (KPC) producer bacteria among hospitalized patients and to establish the colonization origin. Methods: This observational and descriptive study analyzed all the reports of rectal swabs positive for bacteria with phenotypes BLEE and KPC from patients admitted to the Hospital San Francisco de Quito, Ecuador, between June 2016 and June 2017. Results: We found that 180 out of 334 included patients (53.89%) were carriers of bacteria with BLEE (44.61%) and KPC (9.28%) phenotypes. The predominant bacteria with phenotype BLEE were Escherichia coli (87.25%), whereas for the KPC phenotype, it was Klebsiella spp. (83.87%). Colonization was present in all age groups, mainly in adults older than 61. Meanwhile, the colonization origin was nosocomial (55.7%) and in the community (37.58%). Conclusions: The high frequency of colonization by bacteria with multidrug-resistant phenotypes in the population across various age groups underscores the significance of our findings. The prevalence of nosocomial acquisition remains high, but the substantial interchange of bacteria from the community suggests a pressing need for revised infection control measures.
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