Intraoperatorive analgesic effect of ketorolaco, meloxicam and ketoprofen by continuous droppping in canals oforosalpingohisterectomy (OSH) surgeries in dogs

Abstract

The present study evaluated the intraoperative pain control in 54 female canines through NSAIDs administered intravenously to continuous dripping in ororosalpingohysterectomy surgeries; Were randomly divided into 9 groups of 6 individuals, the doses used were: ketoprofen (F1) 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg; Meloxicam (F2) 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg and ketorolac (F3) 0.12 mg/kg, 0.2 mg/kg, 0.5 mg/kg. We measured: Heart Rate, Respiratory Rate, Oxygen Saturation, Mean Arterial Pressure and Temperature. Postoperative analgesia was assessed using the modified Glasgow scale. Before and after each procedure the NSAID measurement profile for hepate and nephrotoxicity was applied considering: Alanine aminotransferase, Aspartate aminotransferase, Gamma glutamyl transferase, Blood urea nitrogen and Creatinine. Using INFOSTAT, we performed analysis of variance and comparison of means with Tukey at 5%. The best results were F1D2 = ketoprofen 1 mg / kg and F2D3 = meloxicam 0.1 mg / kg, with minimal variation in most somatic markers for pain. All groups presented low pain scores for modified Glasgow scale and no variation was observed in NSAID protocols, validating then the use of ketorolac, meloxicam and ketoprofen by continuous drip in the anesthetic maintenance phase