META-ANALYSIS ON APOPTOTIC CASCADE PROTEINS AS NEW MOLECULAR TARGETS IN BREAST AND CERVICAL CANCER

Abstract

Apoptosis is a mechanism that involves cells dying in a programmed manner altering morphological modifications through the cleavage of proteins that has an essential role in the enzymatic activity of effector caspases, such as caspase 3, 6 and 7. The aberrant expression of antiapoptotic proteins prevails in different cancers and it has been shown that this type of protein participates in the growth and maintenance of malignant neoplasms. The objective of this research is to evaluate the best available scientific evidence about apoptotic cascade proteins as new molecular targets in breast and cervical cancer. A meta-analysis with a systematic review of the literature using the PRISMA methodology was carried out on apoptotic cascade proteins as new molecular targets in breast and cervical cancer by searching articles in the WOS, Scopus, PubMed, ProQuest, Embase, Redalyc, Ovid, Medline, DynaMed and ClinicalKey databases during the period 2018-2023. The systematic review provided a total of 52,374 records, of which 100 were eligible; Of these, 60 did not provide new data, including 40 scientific articles. The proteins that participate in the pathways of the apoptotic cascade opens the gap to study in great depth the different mechanisms of interaction, since being considered as new molecular targets will allow to be used for prognostic and therapeutic purposes in breast and cervical cancer, in order to provide new possibilities in the control and / or cure of malignant neoplasms.