Pediatric Multisystemic Inflammatory Syndrome temporarily associated with SARS-CoV-2: a new challenge in light of the evidence.

Abstract

In children, the course of COVID-19 is benign due to their low susceptibility compared to those of adults, although it is not clear why most children are asymptomatic; in addition to the presence of a new condition, similar to Kawasaki disease. The objective of this research is to present a systematic review with the existing information on the Pediatric Multisystemic Inflammatory Syndrome temporarily associated with SARS-CoV-2 in an organized way. For this, the main medical search engines on the Internet were used. Based on strict selection criteria, we seek to clarify whether it is necessary to unify diagnostic criteria, classification, and management for this new nosological entity, which allows the implementation of adapted protocols considering that a number of children with PIMS-TS improve with medical attention, others worsen rapidly, endangering their lives, it is suggested that SARS-CoV-2 is an immunomodulatory factor, which can be modified by environmental factors, related to the etiological agent as well. The most widely used complementary tests are echocardiography, hemogram, inflammation markers, myocardial damage markers and CRP and serology for SARS-CoV-2. The multifaceted nature of the disease warrants multi-specialized management in highly complex medical centers, considering the individuality of the cases. Treatment, in-hospital evolution, and follow-up will depend on the cases