Identification of potential therapeutic targets in type 2 diabetes mellitus (T2DM) based on bioinformatics studies.

Main Article Content

David Guevara Proaño
Cinthia Galarza Galarza
Luis Varela Polit
Cristian Galarza Galarza

Abstract

Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance and dysfunction of the beta cells of the pancreas, resulting in elevated blood glucose levels. Elevated blood glucose levels can lead to disorders of the circulatory, nervous, and immune systems. The aim of this study was to identify potential therapeutic targets by applying bioinformatics techniques and biological databases to study genes that show association and therapeutic potential to treat the disease. Computer-aided drug design methodology was used, molecular docking and virtual screening techniques were applied to identify binding sites with desirable drugability characteristics where chemical compounds and commercial ligands were docked. The docking energy in the different protein-ligand complexes was evaluated, and those with the highest stability were chosen. Virtual screening showed several chemical compounds and commercial drugs whose affinity energy ranged from -9.3 to -9.8 kcal/mol. The protein IRS-1 was identified as a therapeutic target, it presented a protein receptor identified in the Protein Data Bank database with 1QQG with a drugability of 0.84, the compounds Zosuquidar, Rimacalib, Uk432097, Mosapramine, Devazepide and Setipiprant were tested, an average affinity energy of -7. 5 kcal/mol establishing them as possible ligands for the therapeutic target, the toxicity analysis confirmed the application of these compounds and drugs as a possible treatment for the disease.

Downloads

Download data is not yet available.

Article Details

How to Cite
Guevara Proaño, D., Galarza Galarza, C. ., Varela Polit, L., & Galarza Galarza, C. . (2023). Identification of potential therapeutic targets in type 2 diabetes mellitus (T2DM) based on bioinformatics studies. Mediciencias UTA, 7(3), 107–122. https://doi.org/10.31243/mdc.uta.v7i3.2067.2023
Section
Original research article
Author Biographies

Cinthia Galarza Galarza, Facultad de Ciencia de la Salud, Universidad Técnica de Ambato, Ambato, Ecuador

 

 

 

 

Luis Varela Polit, Hospital Metropolitano, Universidad Internacional del Ecuador, Quito, Ecuador

 

 

 

 

Cristian Galarza Galarza, Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología, Universidad Técnica de Ambato, Ambato

 

 

 

 

Similar Articles

<< < 3 4 5 6 7 8 9 10 11 12 > >> 

You may also start an advanced similarity search for this article.